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Roland Seifert Selected Research

1- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazine

11/2015Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis.
11/2013The dual H3/4R antagonist thioperamide does not fully mimic the effects of the 'standard' H4R antagonist JNJ 7777120 in experimental murine asthma.
1/2012Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation.
11/2009Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor.

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Roland Seifert Research Topics

Disease

10Asthma (Bronchial Asthma)
01/2021 - 11/2009
10Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome)
06/2016 - 08/2002
9Lymphoma (Lymphomas)
01/2020 - 09/2002
7Neuroblastoma
09/2014 - 06/2005
6Colitis
04/2020 - 09/2014
6Anthrax
07/2015 - 03/2009
5Infections
01/2021 - 08/2011
5Heart Failure
01/2016 - 04/2007
4Inflammation (Inflammations)
07/2021 - 01/2010
3Hypersensitivity (Allergy)
01/2021 - 11/2009
3Anaphylaxis (Anaphylactic Shock)
01/2021 - 01/2014
3Neoplasms (Cancer)
01/2020 - 04/2007
3Eosinophilia
04/2015 - 01/2012
3Whooping Cough (Pertussis)
04/2012 - 05/2004
2Fibrosis (Cirrhosis)
01/2022 - 07/2021
2Atopic Dermatitis (Atopic Eczema)
05/2011 - 04/2011
2Pruritus (Itching)
05/2011 - 04/2011
1Diabetic Nephropathies (Diabetic Nephropathy)
01/2022
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2022
1Cardiogenic Shock
01/2022
1Hypothermia
01/2022
1Kidney Diseases (Kidney Disease)
01/2022
1Hypoxia (Hypoxemia)
01/2022
1Communicable Diseases (Infectious Diseases)
11/2021
1Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
07/2021
1Virus Diseases (Viral Diseases)
01/2021
1Carcinogenesis
04/2020
1Confusion (Bewilderment)
01/2020
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2020
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
01/2020
1Ulcerative Colitis
01/2018
1Lung Diseases (Lung Disease)
01/2018
1Myeloid Leukemia (Leukemia, Myelocytic)
01/2016
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2016
1Acute Erythroblastic Leukemia (Erythroleukemia)
01/2016
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2016
1Osteoporosis
12/2015

Drug/Important Bio-Agent (IBA)

15Adenylyl Cyclases (Adenylyl Cyclase)IBA
01/2016 - 04/2003
14Histamine (Histamine Dihydrochloride)FDA Link
04/2020 - 11/2009
8purineIBA
01/2016 - 08/2002
6cyclic 3',5'-uridine monophosphateIBA
01/2020 - 05/2014
6Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA
11/2015 - 06/2005
6edema factorIBA
07/2015 - 05/2004
5Histamine Receptors (Histamine Receptor)IBA
04/2020 - 01/2014
5sodium sulfate (sodium bisulfate)FDA LinkGeneric
04/2020 - 11/2015
5Histamine H4 ReceptorsIBA
01/2020 - 01/2010
5Proteins (Proteins, Gene)FDA Link
01/2018 - 09/2002
5TransferasesIBA
07/2012 - 06/2005
5HypoxanthineIBA
07/2012 - 06/2005
5GTP-Binding Proteins (G-Protein)IBA
08/2011 - 08/2002
4Anti-Bacterial Agents (Antibiotics)IBA
11/2021 - 03/2009
4CytokinesIBA
07/2021 - 11/2015
4Dextrans (Dextran)FDA Link
04/2020 - 11/2015
4Pharmaceutical PreparationsIBA
01/2020 - 02/2014
4Cyclic NucleotidesIBA
01/2018 - 12/2014
4EnzymesIBA
11/2015 - 06/2005
41- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazineIBA
11/2015 - 11/2009
4Calmodulin (Calcium-Dependent Activator Protein)IBA
07/2015 - 09/2007
4LigandsIBA
09/2014 - 11/2009
24'-N,N-dimethylamino-4-aminoazobenzeneIBA
01/2021 - 01/2014
2Antiviral Agents (Antivirals)IBA
01/2021 - 02/2014
2NucleosidesIBA
01/2020 - 06/2007
2OvalbuminIBA
04/2015 - 01/2012
2Immunoglobulin E (IgE)IBA
11/2013 - 01/2012
2AllergensIBA
11/2013 - 01/2012
2ColforsinIBA
07/2012 - 04/2003
2ExotoxinsIBA
01/2012 - 03/2009
2Pyrilamine (Mepyramine)FDA Link
01/2012 - 11/2009
2Pyrimidine NucleotidesIBA
08/2009 - 03/2009
2Nucleoside-TriphosphataseIBA
06/2007 - 06/2005
2Guanosine Triphosphate (GTP)IBA
01/2006 - 04/2003
2Guanosine 5'-O-(3-Thiotriphosphate)IBA
12/2003 - 04/2003
1BAY 58-2667IBA
01/2022
1Thrombospondin 1IBA
01/2022
1Streptozocin (Streptozotocin)FDA Link
01/2022
1CreatinineIBA
01/2022
1OctopamineIBA
01/2022
1Biomarkers (Surrogate Marker)IBA
01/2022
1RNA (Ribonucleic Acid)IBA
01/2022
12- (2- Chloro- 4- (methylsulfonyl)- 3- ((2,2,2- trifluoroethoxy)methyl)benzoyl)- 1,3- cyclohexanedione (BAY 747)IBA
07/2021
1CollagenIBA
07/2021
1bis(3',5')-cyclic diguanylic acidIBA
01/2021
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
01/2021
1InterferonsIBA
01/2021
1CarcinogensIBA
04/2020
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
04/2020
1AzoxymethaneIBA
04/2020
1EstersIBA
01/2020
1Cytostatic AgentsIBA
01/2020
1Interleukin-2 (IL2)IBA
01/2020
1GuanosineIBA
01/2020
1NucleotidesIBA
01/2020
1Type III Secretion SystemsIBA
01/2018
1Sulfonic AcidsIBA
01/2017
1Uric Acid (Urate)IBA
06/2016
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
01/2016
1Multidrug Resistance-Associated ProteinsIBA
01/2016
1Soluble Guanylyl CyclaseIBA
12/2015

Therapy/Procedure

7Therapeutics
01/2022 - 01/2014
2Critical Care (Surgical Intensive Care)
01/2021 - 01/2014